The cost of renting a home in Panama will be affected by the location of the house, primarily. If you want to stay in the heart of the city or nearby it is going to be a whole different market rather than relocating to a neighborhood outside the city. Since there are not as many houses as apartments for rent and sale, houses are a little bit more expensive. For a middle class house located in San Francisco it could start from $1,800 up to $4,000 and even more. However if you are comfortable not being in the heart of the city, chances are you could find a house for $1,200 or even a little bit less than that.